| April 3-5 | The Randox Grand National Festival | Sports | Aintree Racecourse |
| April 4 | André Rieu 2025 Concert Tour | Music | M&S Bank Arena |
| April 4 | Latino Fest (Liverpool) 2025 | Music | Arts Club |
| April 4 | Ladies Day Brunch for Grand National 2025 | Social | DoubleTree By Hilton Liverpool |
| April 5 | The Music of Zimmer vs Williams | Music | Liverpool Philharmonic Hall |
| April 5 | Michael Ball & Alfie Boe: Together At Home | Music | M&S Bank Arena |
| April 5 | Grand National 2025 After Racing Party | Social | Koukash |
| April 7 | Andy & the Odd Socks: Are You Ready To Rock? | Family/Music | Liverpool Philharmonic Hall |
| April 8-12 | The Gruffalo – Live on Stage! | Family/Theatre | Liverpool Playhouse |
| April 9 | Jeff Wayne’s The War of the Worlds – Alive on Stage! | Music/Theatre | M&S Bank Arena |
| April 10 | Inspirational Women From Liverpool’s Past & History Walking Tour | Cultural/Tour | Various Liverpool Locations |
| April 22-26 | Calamity Jane | Theatre/Musical | Liverpool Empire |
| April 23 | Quay Business Forum | Business | Egerton House, Birkenhead |
| April 27 | Liverpool Women’s Hospital Charity Women of Power | Charity | Venue on Seel Street, Liverpool L1 4AU |
| April 28-29 | Gary Barlow – The Songbook Tour 2025 | Music | Liverpool Empire |
| April 30 | Liverpool City Region Tech Climbers 2025 List Reveal Event | Business/Tech | One Fine Day, Cotton Exchange, Liverpool |
| April 30 | Nikita Kuzmin – Midnight Dancer | Dance | Liverpool Empire |
